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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 3 — Mar. 7, 2007

Free-space fluorescence molecular tomography utilizing 360° geometry projections

Nikolaos Deliolanis, Tobias Lasser, Damon Hyde, Antoine Soubret, Jorge Ripoll, and Vasilis Ntziachristos  »View Author Affiliations

Optics Letters, Vol. 32, Issue 4, pp. 382-384 (2007)

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Fluorescence tomography of diffuse media can yield optimal three-dimensional imaging when multiple projections over 360 ° geometries are captured, compared with limited projection angle systems such as implementations in the slab geometry. We demonstrate how it is possible to perform noncontact, 360 ° projection fluorescence tomography of mice using CCD-camera-based detection in free space, i.e., in the absence of matching fluids. This approach achieves high spatial sampling of photons propagating through tissue and yields a superior information content data set compared with fiber-based 360 ° implementations. Reconstruction feasibility using 36 projections in 10° steps is demonstrated in mice.

© 2007 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 2, 2006
Revised Manuscript: November 8, 2006
Manuscript Accepted: November 9, 2006
Published: January 26, 2007

Virtual Issues
Vol. 2, Iss. 3 Virtual Journal for Biomedical Optics

Nikolaos Deliolanis, Tobias Lasser, Damon Hyde, Antoine Soubret, Jorge Ripoll, and Vasilis Ntziachristos, "Free-space fluorescence molecular tomography utilizing 360° geometry projections," Opt. Lett. 32, 382-384 (2007)

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