OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 9 — Sep. 8, 2008

Label-free biosensor by protein grating coupler on planar optical waveguides

Zhian Lai, Yuli Wang, Nancy Allbritton, G.-P. Li, and Mark Bachman  »View Author Affiliations


Optics Letters, Vol. 33, Issue 15, pp. 1735-1737 (2008)
http://dx.doi.org/10.1364/OL.33.001735


View Full Text Article

Enhanced HTML    Acrobat PDF (445 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report a diffraction-based, label-free biosensor on the surface of a planar optical waveguide. By selectively immobilizing proteins on an optical waveguide, the proteins can form the ridge/valley of a latent image optical grating. Binding events with patterned surface proteins dynamically increase grating height and cause an increase in light coupling out of the waveguide. We demonstrate the efficacy of this strategy for protein detection and present the design and fabrication of a device.

© 2008 Optical Society of America

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(230.1950) Optical devices : Diffraction gratings
(230.7390) Optical devices : Waveguides, planar
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Optical Devices

History
Original Manuscript: February 19, 2008
Revised Manuscript: June 5, 2008
Manuscript Accepted: June 16, 2008
Published: July 29, 2008

Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Zhian Lai, Yuli Wang, Nancy Allbritton, G.-P. Li, and Mark Bachman, "Label-free biosensor by protein grating coupler on planar optical waveguides," Opt. Lett. 33, 1735-1737 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-15-1735


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. P. B. Luppa, L. J. Sokoll, and D. W. Chan, Clin. Chim. Acta 314, 1 (2001). [CrossRef] [PubMed]
  2. M. A. Cooper, Nat. Rev. Drug Discovery 1, 515 (2002). [CrossRef]
  3. B. Liedberg, C. Nylander, and I. Lundstrom, Sens. Actuators A 4, 299 (1983). [CrossRef]
  4. J. Fritz, M. K. Baller, H. P. Lang, H. Rothuizen, P. Vettiger, E. Meyer, H. J. Guntherodt, C. Gerber, and J. K. Gimzewski, Science 288, 316 (2000). [CrossRef] [PubMed]
  5. P. M. Nellen, K. Tiefenthaler, and W. Lukosz, Sens. Actuator A 15, 285 (1988). [CrossRef]
  6. K. Tiefenthaler and W. Lukosz, J. Opt. Soc. Am. B 6, 209 (1989). [CrossRef]
  7. M. Wiki and R. E. Kunz, Opt. Lett. 25, 463 (2000). [CrossRef]
  8. K. Nakanishi, H. Muguruma, and I. Karube, Anal. Chem. 68, 1695 (1996). [CrossRef] [PubMed]
  9. Y. G. Tsay, C. I. Lin, J. Lee, E. K. Gustafson, R. Appelqvist, P. Magginetti, R. Norton, N. Teng, and D. Charlton, Clin. Chem. 37, 1502 (1991). [PubMed]
  10. J. B. Goh, R. W. Loo, R. A. McAloney, and M. C. Goh, Anal. Bioanal. Chem. 374, 54 (2002). [CrossRef] [PubMed]
  11. J. B. Goh, P. L. Tam, R. W. Loo, and M. C. Goh, Anal. Biochem. 313, 262 (2003). [CrossRef] [PubMed]
  12. J. B. Goh, R. W. Loo, and M. C. Goh, Sens. Actuators B 106, 243 (2005). [CrossRef]
  13. V. Borisenko, W. Hu, P. Tam, I. Chen I, J. F. Houle, and W. Ausserer, Clin. Chem. 52, 2168 (2006). [CrossRef]
  14. T. Tamir and S. T. Peng, Appl. Phys. 14, 235 (1977). [CrossRef]
  15. D. Marcuse, J. Lightwave Technol. 5, 113 (1987). [CrossRef]
  16. H. Schift, L. J. Heyderman, C. Padeste, and J. Gobrecht, Microelectron. Eng. 61-62, 423 (2002). [CrossRef]
  17. J. F. Mooney, A. J. Hunt, J. R. McIntosh, C. A. Liberko, D. M. Walba, and C. T. Rogers, Proc. Natl. Acad. Sci. USA 93, 12,287 (1996). [CrossRef]
  18. K. L. Christman, V. D. Enriquez, and H. D. Maynard, Soft Matter 2, 928 (2006). [CrossRef]
  19. C. L. Chang, G. Acharya, and C. A. Savran, Appl. Phys. Lett. 90, 233901 (2007). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited