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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 9 — Sep. 8, 2008

Fluorescent optical tomography with large data sets

George Y. Panasyuk, Zheng-Min Wang, John C. Schotland, and Vadim A. Markel  »View Author Affiliations


Optics Letters, Vol. 33, Issue 15, pp. 1744-1746 (2008)
http://dx.doi.org/10.1364/OL.33.001744


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Abstract

In recent years, optical tomography (OT) of highly scattering biological samples has increasingly relied on noncontact CCD-based imaging devices that can record extremely large data sets, with up to 109 independent measurements per sample. Reconstruction of such data sets requires fast algorithms. The latter have been developed and applied experimentally in our previous work to imaging of the intrinsic absorption coefficient of highly scattering media. However, it is widely recognized that the use of fluorescent contrast agents in OT has the potential to significantly enhance the technique. We show that the algorithms previously developed by us can be modified to reconstruct the concentration of fluorescent contrast agents.

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 3, 2008
Revised Manuscript: June 25, 2008
Manuscript Accepted: June 30, 2008
Published: July 30, 2008

Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics

Citation
George Y. Panasyuk, Zheng-Min Wang, John C. Schotland, and Vadim A. Markel, "Fluorescent optical tomography with large data sets," Opt. Lett. 33, 1744-1746 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-15-1744

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