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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 11 — Oct. 22, 2008

Confocal diffraction phase microscopy of live cells

Niyom Lue, Wonshik Choi, Kamran Badizadegan, Ramachandra R. Dasari, Michael S. Feld, and Gabriel Popescu  »View Author Affiliations


Optics Letters, Vol. 33, Issue 18, pp. 2074-2076 (2008)
http://dx.doi.org/10.1364/OL.33.002074


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Abstract

We present a new quantitative phase microscopy technique, confocal diffraction phase microscopy, which provides quantitative phase measurements from localized sites on a sample with high sensitivity. The technique combines common-path interferometry with confocal microscopy in a transmission geometry. The capability of the technique for static imaging is demonstrated by imaging polystyrene microspheres and live HT29 cells, while dynamic imaging is demonstrated by quantifying the nanometer scale fluctuations of red blood cell membranes.

© 2008 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1530) Medical optics and biotechnology : Cell analysis
(180.0180) Microscopy : Microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: May 6, 2008
Revised Manuscript: July 23, 2008
Manuscript Accepted: July 24, 2008
Published: September 9, 2008

Virtual Issues
Vol. 3, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Niyom Lue, Wonshik Choi, Kamran Badizadegan, Ramachandra R. Dasari, Michael S. Feld, and Gabriel Popescu, "Confocal diffraction phase microscopy of live cells," Opt. Lett. 33, 2074-2076 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-18-2074

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