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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 12 — Dec. 1, 2008

Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler  »View Author Affiliations

Optics Letters, Vol. 33, Issue 19, pp. 2233-2235 (2008)

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Multispeckle diffusing-wave spectroscopy (DWS) is used to measure blood flow transients in the human visual cortex following stimulation by 7.5 Hz full-field and checkerboard flickering. The average decay time τ d characterizing the decay of the DWS autocorrelation function shows a biphasic behavior; within about 2 s after stimulation onset, τ d increases rapidly to about 6% above the baseline value. At later times, τ d slowly decreases and reaches a steady-state value about 5% below the baseline value after about 15 s . The initial increase of the DWS signal suggests a transient reduction of the cortical blood flow velocity shortly after stimulation onset. Measurements of this transient response at different positions over the primary visual cortex show a spatial pattern different from the one measured by electroencephalography.

© 2008 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5280) Medical optics and biotechnology : Photon migration
(290.1350) Scattering : Backscattering
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering

ToC Category:

Original Manuscript: July 9, 2008
Manuscript Accepted: August 8, 2008
Published: September 29, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, "Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy," Opt. Lett. 33, 2233-2235 (2008)

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