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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 12 — Dec. 1, 2008

Analysis of the depth resolution limit of luminescence diffuse optical imaging

M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati  »View Author Affiliations

Optics Letters, Vol. 33, Issue 20, pp. 2290-2292 (2008)

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We introduce a methodology to determine quantitatively the depth resolution limit in luminescence diffuse optical imaging. The approach is based on a Cramer–Rao statistical analysis, a noise model, and calculations of photon transport in tissues. We illustrate the method in the case of luminescence imaging in a brain–skull model, showing its potential applications in molecular imaging on small animals.

© 2008 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 1, 2008
Manuscript Accepted: August 11, 2008
Published: October 3, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati, "Analysis of the depth resolution limit of luminescence diffuse optical imaging," Opt. Lett. 33, 2290-2292 (2008)

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