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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 2 — Feb. 10, 2009

Integration of laser trapping for continuous and selective monitoring of photothermal response of a single microparticle

Srivathsan Vasudevan, George C.K. Chen, and Balpreet Singh Ahluwalia  »View Author Affiliations


Optics Letters, Vol. 33, Issue 23, pp. 2779-2781 (2008)
http://dx.doi.org/10.1364/OL.33.002779


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Abstract

Photothermal response (PTR) is an established pump and probe technique for real-time sensing of biological assays. Continuous and selective PTR monitoring is difficult owing to the Brownian motion changing the relative position of the target with respect to the beams. Integration of laser trapping with PTR is proposed as a solution. The proposed method is verified on red polystyrene microparticles. PTR is continuously monitored for 30 min . Results show that the mean relaxation time variation of the acquired signals is less than 5%. The proposed method is then applied to human red blood cells for continuous and selective PTR.

© 2008 Optical Society of America

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(350.6830) Other areas of optics : Thermal lensing

ToC Category:
Lasers and Laser Optics

History
Original Manuscript: July 30, 2008
Revised Manuscript: October 8, 2008
Manuscript Accepted: October 16, 2008
Published: November 20, 2008

Virtual Issues
Vol. 4, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Srivathsan Vasudevan, George C. K. Chen, and Balpreet Singh Ahluwalia, "Integration of laser trapping for continuous and selective monitoring of photothermal response of a single microparticle," Opt. Lett. 33, 2779-2781 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-23-2779


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