Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels
Optics Letters, Vol. 33, Issue 24, pp. 2967-2969 (2008)
http://dx.doi.org/10.1364/OL.33.002967
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Abstract
We describe a bidirectional color Doppler Fourier-domain optical coherence tomography system capable of measuring absolute velocities of moving scatterers by illuminating the sample with two linearly and orthogonally polarized beams, incident at a known angle on the sample. The velocity calculation is independent of the exact orientation of the velocity vector in the detection plane. First measurements were performed on a rotating disk driven at well-defined velocities and tilted by various small angles. Our results indicate a high correlation between preset and calculated velocities (correlation coefficient 0.999) and the independency of these velocities from the tilting angle of the disk. We demonstrate that bidirectional color Doppler optical coherence tomography allows for the measurement of absolute blood flow values in vivo in human retinal vessels.
© 2008 Optical Society of America
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: August 26, 2008
Revised Manuscript: October 31, 2008
Manuscript Accepted: November 2, 2008
Published: December 8, 2008
Virtual Issues
Vol. 4, Iss. 2 Virtual Journal for Biomedical Optics
Citation
René M. Werkmeister, Nikolaus Dragostinoff, Michael Pircher, Erich Götzinger, Christoph K. Hitzenberger, Rainer A. Leitgeb, and Leopold Schmetterer, "Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels," Opt. Lett. 33, 2967-2969 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-24-2967
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