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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Interferometric polarization coherent anti-Stokes Raman scattering (IP-CARS) microscopy

Fake Lu, Wei Zheng, Colin Sheppard, and Zhiwei Huang  »View Author Affiliations


Optics Letters, Vol. 33, Issue 6, pp. 602-604 (2008)
http://dx.doi.org/10.1364/OL.33.000602


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Abstract

We report a novel interferometry-based polarization coherent anti-Stokes Raman scattering (IP-CARS) implementation for effectively suppressing the nonresonant background while significantly amplifying the resonant signal for vibrational imaging. By modulating the phase difference between the two interference CARS signals generated from the same sample and measuring the peak-to-peak intensity of the periodically modulated interference CARS signal, the IP-CARS technique yields a sixfold improvement in the signal-to-background ratio compared with conventional CARS while providing an approximately 20-fold amplification of the resonant CARS signal compared with conventional polarization CARS. We demonstrate this method by imaging 4.69 μ m polystyrene beads and unstained human epithelial cells immersed in water.

© 2008 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(180.3170) Microscopy : Interference microscopy
(180.6900) Microscopy : Three-dimensional microscopy
(190.3970) Nonlinear optics : Microparticle nonlinear optics
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering

ToC Category:
Microscopy

History
Original Manuscript: December 10, 2007
Revised Manuscript: February 9, 2008
Manuscript Accepted: February 12, 2008
Published: March 14, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Fake Lu, Wei Zheng, Colin Sheppard, and Zhiwei Huang, "Interferometric polarization coherent anti-Stokes Raman scattering (IP-CARS) microscopy," Opt. Lett. 33, 602-604 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-33-6-602

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