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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 10 — Oct. 2, 2009

Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves

Euiheon Chung, Yang-Hyo Kim, Wai Teng Tang, Colin J.R. Sheppard, and Peter T.C. So  »View Author Affiliations


Optics Letters, Vol. 34, Issue 15, pp. 2366-2368 (2009)
http://dx.doi.org/10.1364/OL.34.002366


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Abstract

The resolution of conventional surface-plasmon-resonance (SPR) imaging has been limited by the diffraction nature of light. A wide-field extended-resolution optical imaging technique, standing-wave SPR fluorescence (SW-SPRF) microscopy, has been developed. Based on evanescent SPR standing waves, SW-SPRF provides lateral resolution approaching 100 nm and offers the advantages of significant signal enhancement and background-noise reduction. SW-SPRF has the potential for sensitive biomolecular detection, nanoscale imaging, and lithographic applications.

© 2009 Optical Society of America

OCIS Codes
(180.0180) Microscopy : Microscopy
(180.2520) Microscopy : Fluorescence microscopy
(180.3170) Microscopy : Interference microscopy
(240.6680) Optics at surfaces : Surface plasmons
(260.6970) Physical optics : Total internal reflection

ToC Category:
Microscopy

History
Original Manuscript: March 13, 2009
Revised Manuscript: June 14, 2009
Manuscript Accepted: July 13, 2009
Published: July 31, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Euiheon Chung, Yang-Hyo Kim, Wai Teng Tang, Colin J. R. Sheppard, and Peter T. C. So, "Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves," Opt. Lett. 34, 2366-2368 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-15-2366


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