Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from 3% to 4%. Spectral analysis was also performed on the acquired data, which improved the processing speed by a factor of 5 compared with a least-square fitting approach. Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties.
© 2009 Optical Society of America
Original Manuscript: July 2, 2009
Manuscript Accepted: August 13, 2009
Published: September 17, 2009
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics
Xing Liang, Marko Orescanin, Kathleen S. Toohey, Michael F. Insana, and Stephen A. Boppart, "Acoustomotive optical coherence elastography for measuring material mechanical properties," Opt. Lett. 34, 2894-2896 (2009)