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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 12 — Nov. 10, 2009

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, and David A. Boas  »View Author Affiliations


Optics Letters, Vol. 34, Issue 20, pp. 3086-3088 (2009)
http://dx.doi.org/10.1364/OL.34.003086


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Abstract

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

© 2009 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5380) Medical optics and biotechnology : Physiology

ToC Category:
Imaging Systems

History
Original Manuscript: September 3, 2009
Revised Manuscript: September 3, 2009
Manuscript Accepted: September 3, 2009
Published: October 6, 2009

Virtual Issues
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, and David A. Boas, "Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography," Opt. Lett. 34, 3086-3088 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-20-3086

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