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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 13 — Dec. 2, 2009

Tailoring the soliton output of a photonic crystal fiber for enhanced two-photon excited luminescence response from fluorescent protein biomarkers and neuron activity reporters

Lyubov V. Doronina, Il’ya V. Fedotov, Aleksandr A. Voronin, Olga I. Ivashkina, Marina A. Zots, Konstantin V. Anokhin, Ekaterina Rostova, Andrei B. Fedotov, and Aleksei M. Zheltikov  »View Author Affiliations


Optics Letters, Vol. 34, Issue 21, pp. 3373-3375 (2009)
http://dx.doi.org/10.1364/OL.34.003373


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Abstract

Dual-cladding photonic crystal fibers (PCFs) with two zero-dispersion points are used to enhance the two-photon excited luminescence (TPL) response from fluorescent protein biomarkers and neuron activity reporters in dye-cell experiments and in in vivo work on transgenic mice and tadpoles. The soliton transmission of ultrashort pulses through a PCF suppresses dispersion-induced temporal pulse spreading, maintaining a high level of field intensity needed for efficient TPL excitation. The soliton self-frequency shift, stabilized against laser power fluctuations by a specific PCF dispersion design, is employed to accurately match the wavelength of the soliton PCF output with the two-photon absorption spectrum of dye or fluorescent protein biomarker molecules, enhancing their TPL response and allowing the laser damage of biotissues to be avoided.

© 2009 Optical Society of America

OCIS Codes
(190.4370) Nonlinear optics : Nonlinear optics, fibers
(060.4005) Fiber optics and optical communications : Microstructured fibers

ToC Category:
Nonlinear Optics

History
Original Manuscript: July 31, 2009
Manuscript Accepted: September 22, 2009
Published: October 28, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Lyubov V. Doronina, Il'ya V. Fedotov, Aleksandr A. Voronin, Olga I. Ivashkina, Marina A. Zots, Konstantin V. Anokhin, Ekaterina Rostova, Andrei B. Fedotov, and Aleksei M. Zheltikov, "Tailoring the soliton output of a photonic crystal fiber for enhanced two-photon excited luminescence response from fluorescent protein biomarkers and neuron activity reporters," Opt. Lett. 34, 3373-3375 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-21-3373

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