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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 1 — Jan. 4, 2010

Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection

A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid  »View Author Affiliations


Optics Letters, Vol. 34, Issue 23, pp. 3598-3600 (2009)
http://dx.doi.org/10.1364/OL.34.003598


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Abstract

We demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 μ m diameter spot and is incorporated in a balanced Mach–Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 μ m spacing grid pattern and are addressed through cascaded 1 × 2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody–antigen reactions using complementary and mismatched immunoglobulin G receptor–analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3   pg / mm 2 .

© 2009 Optical Society of America

OCIS Codes
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(130.3120) Integrated optics : Integrated optics devices
(130.6010) Integrated optics : Sensors

ToC Category:
Integrated Optics

History
Original Manuscript: August 7, 2009
Revised Manuscript: October 2, 2009
Manuscript Accepted: October 16, 2009
Published: November 16, 2009

Virtual Issues
Vol. 5, Iss. 1 Virtual Journal for Biomedical Optics
November 25, 2009 Spotlight on Optics

Citation
A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, G. Lopinski, A. Delâge, J. Lapointe, C. C. Luebbert, Q. Y. Liu, P. Cheben, and J. H. Schmid, "Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection," Opt. Lett. 34, 3598-3600 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-23-3598


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References

  1. B. J. Luff, J. S. Wilkinson, J. Piehler, U. Hollenback, J. Ingenhoff, and N. Fabricius, J. Lightwave Technol. 16, 583 (1998). [CrossRef]
  2. B. Sepulveda, J. S. del Rio, M. Moreno, F. J. Blanco, K. Mayora, C. Dominguez, and L. M. Lechuga, J. Opt. A 8, S561 (2006). [CrossRef]
  3. A. Densmore, D.-X. Xu, P. Waldron, S. Janz, P. Cheben, J. Lapointe, A. Delâge, B. Lamontagne, J. H. Schmid, and E. Post, IEEE Photon. Technol. Lett. 18, 2520 (2006). [CrossRef]
  4. A. Densmore, D.-X. Xu, S. Janz, P. Waldron, T. Mischki, G. Lopinski, A. Delâge, J. Lapointe, P. Cheben, B. Lamontagne, and J. H. Schmid, Opt. Lett. 33, 596 (2008). [CrossRef] [PubMed]
  5. A. M. Armani, R. P. Kulkarni, S. E. Fraser, R. C. Flagan, and K. J. Vahala, Science 317, 783 (2007). [CrossRef] [PubMed]
  6. R. W. Boyd and J. E. Heebner, Appl. Opt. 40, 5742 (2001). [CrossRef]
  7. D. X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, Opt. Express 16, 15137 (2008). [CrossRef] [PubMed]
  8. K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, Opt. Express 15, 7610 (2007). [CrossRef] [PubMed]
  9. A. Yalcin, K. C. Popat, J. C. Aldridge, T. A. Desai, J. Hryniewicz, N. Chbouki, B. E. Little, O. King, V. Van, S. Chu, D. Gill, M. Anthes-Washburn, M. S. Unlu, and B. B. Goldberg, IEEE J. Sel. Top. Quantum Electron. 12, 148 (2006). [CrossRef]
  10. A. Ksendzov and Y. Lin, Opt. Lett. 30, 3344 (2005). [CrossRef]
  11. W. Lukosz, Biosens. Bioelectron. 6, 215 (1991). [CrossRef]
  12. H. Elwing, Biomaterials 19, 397 (1998). [CrossRef] [PubMed]

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