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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 4 — Apr. 1, 2009

Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging

Melissa C. Skala, Andrew Fontanella, Hansford Hendargo, Mark W. Dewhirst, and Joseph A. Izatt  »View Author Affiliations


Optics Letters, Vol. 34, Issue 3, pp. 289-291 (2009)
http://dx.doi.org/10.1364/OL.34.000289


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Abstract

We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation ( ρ = 0.89 , p = 9 × 10 6 , N = 15 ) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation ( ρ = 0.56 , p = 0.03 , N = 15 ).

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 27, 2008
Manuscript Accepted: November 27, 2008
Published: January 26, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Melissa C. Skala, Andrew Fontanella, Hansford Hendargo, Mark W. Dewhirst, and Joseph A. Izatt, "Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging," Opt. Lett. 34, 289-291 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-3-289


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