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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 4 — Apr. 1, 2009

Normalized Born ratio for fluorescence optical projection tomography

Claudio Vinegoni, Daniel Razansky, Jose-Luiz Figueiredo, Matthias Nahrendorf, Vasilis Ntziachristos, and Ralph Weissleder  »View Author Affiliations


Optics Letters, Vol. 34, Issue 3, pp. 319-321 (2009)
http://dx.doi.org/10.1364/OL.34.000319


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Abstract

We present a normalized Born approach for fluorescence optical projection tomography that takes into account tissue absorption properties. This approach can be particularly useful to study fluorochrome distribution within tissue. We use the algorithm to three-dimensionally reconstruct and characterize a fluorescein isothiocyanate containing absorptive phantom and an infarcted mouse heart previously injected with a fluorescent molecular probe.

© 2009 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 9, 2008
Revised Manuscript: December 5, 2008
Manuscript Accepted: December 9, 2008
Published: January 27, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Claudio Vinegoni, Daniel Razansky, Jose-Luiz Figueiredo, Matthias Nahrendorf, Vasilis Ntziachristos, and Ralph Weissleder, "Normalized Born ratio for fluorescence optical projection tomography," Opt. Lett. 34, 319-321 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-3-319


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References

  1. J. Sharpe, U. Ahlgren, P. Perry, B. Hill, A. Ross, J. Hecksher-Sorensen, R. Baldock, and D. Davidson, Science 296, 541 (2002). [CrossRef] [PubMed]
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  3. M. Oldham, H. Sakhalkar, Y. M. Wang, P. Y. Guo, T. Oliver, R. Bentley, Z. Vujaskovic, and M. Dewhirst, J. Biomed. Opt. 12, 1 (2007). [CrossRef]
  4. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893 (2001). [CrossRef]

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