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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

High-throughput acousto-optic-tunable-filter-based time-resolved fluorescence spectrometer for optical biopsy

Ye Yuan, Ji-Young Hwang, Mowleswaran Krishnamoorthy, Kuntao Ye, Yuan Zhang, Jin Ning, Roy C. Wang, M. Jamal Deen, and Qiyin Fang  »View Author Affiliations


Optics Letters, Vol. 34, Issue 7, pp. 1132-1134 (2009)
http://dx.doi.org/10.1364/OL.34.001132


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Abstract

Time-resolved fluorescence spectroscopy has been studied to perform minimally invasive optical biopsy in clinical diagnostics. A critical barrier preventing current time-resolved techniques from clinical studies is their impractically long data acquisition time. We have developed an acousto-optic-tunable-filter (AOTF)-based time-resolved fluorescence spectrometer, which is capable of near real-time data acquisition. Both first-order diffraction beams are collected in this AOTF spectrometer, which results in significantly improved overall throughput. Using standard fluorescence dyes, we have demonstrated that this spectrometer can acquire 200 nm time-resolved spectra within 4 s , while its throughput is comparable to a grating-based spectrometer.

© 2009 Optical Society of America

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 4, 2008
Revised Manuscript: January 12, 2009
Manuscript Accepted: January 26, 2009
Published: March 31, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Ye Yuan, Ji-Young Hwang, Mowleswaran Krishnamoorthy, Kuntao Ye, Yuan Zhang, Jin Ning, Roy C. Wang, M. Jamal Deen, and Qiyin Fang, "High-throughput acousto-optic-tunable-filter-based time-resolved fluorescence spectrometer for optical biopsy," Opt. Lett. 34, 1132-1134 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-7-1132


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