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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Enhanced spatial resolution in third-harmonic microscopy through polarization switching

Omid Masihzadeh, Philip Schlup, and Randy A. Bartels  »View Author Affiliations


Optics Letters, Vol. 34, Issue 8, pp. 1240-1242 (2009)
http://dx.doi.org/10.1364/OL.34.001240


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Abstract

Enhanced spatial resolution in third-harmonic generation (THG) microscopy is demonstrated through manipulation of the polarization state across the focal field of a microscope. Enhancements in resolution of up to a factor of 2 are observed for a focal field linearly polarized at the center and switched to circularly polarized at the beam edges. As THG scattering is suppressed for circular polarization, the THG signal diameter is reduced, improving spatial resolution.

© 2009 Optical Society of America

OCIS Codes
(100.5070) Image processing : Phase retrieval
(180.5810) Microscopy : Scanning microscopy
(230.6120) Optical devices : Spatial light modulators
(260.5430) Physical optics : Polarization
(320.7110) Ultrafast optics : Ultrafast nonlinear optics
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Microscopy

History
Original Manuscript: January 23, 2009
Manuscript Accepted: February 28, 2009
Published: April 10, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Omid Masihzadeh, Philip Schlup, and Randy A. Bartels, "Enhanced spatial resolution in third-harmonic microscopy through polarization switching," Opt. Lett. 34, 1240-1242 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-34-8-1240


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