In this study, near-IR tomography was implemented in the wavelength range from $661\text{to}948\mathrm{nm}$ to characterize breast tumors in vivo. Frequency-domain measurements provide amplitude and phase transmitted at wavelengths below $850\mathrm{nm}$ , where photomultiplier tube detection is efficient. Continuous-wave detection at additional longer wavelengths (903, 912, and $948\mathrm{nm}$ ) was collected using a CCD-based spectrometer. Phantom validation experiments showed improved accuracy in hemoglobin and water concentrations using this technique. Three women with malignant breast tumors were studied. The addition of cw data at longer wavelengths increased the recovered contrast of water in the tumor region relative to surrounding tissue and allowed quantification of lipid.

© 2009 Optical Society of America

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