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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 10 — Jul. 19, 2010

Focal modulation microscopy: a theoretical study

Shau Poh Chong, Chee Howe Wong, Colin J. R. Sheppard, and Nanguang Chen  »View Author Affiliations


Optics Letters, Vol. 35, Issue 11, pp. 1804-1806 (2010)
http://dx.doi.org/10.1364/OL.35.001804


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Abstract

Focal modulation microscopy is an emerging fluorescence microscopy technique for in vivo imaging of thick biological tissues. Here, we present a theoretical study to assess its performance. The scalar diffraction theory is combined with Monte Carlo simulation to evaluate the signal-to-background ratio at various depths. The performance of confocal microscopy with a similar optical setup is also evaluated for comparison.

© 2010 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(180.2520) Microscopy : Fluorescence microscopy
(290.7050) Scattering : Turbid media

ToC Category:
Imaging Systems

History
Original Manuscript: March 19, 2010
Revised Manuscript: April 18, 2010
Manuscript Accepted: April 20, 2010
Published: May 20, 2010

Virtual Issues
Vol. 5, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Shau Poh Chong, Chee Howe Wong, Colin J. R. Sheppard, and Nanguang Chen, "Focal modulation microscopy: a theoretical study," Opt. Lett. 35, 1804-1806 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-11-1804

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