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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Estimation of oxygen saturation from erythrocytes by high-resolution spectroscopic optical coherence tomography

Ji Yi and Xu Li  »View Author Affiliations


Optics Letters, Vol. 35, Issue 12, pp. 2094-2096 (2010)
http://dx.doi.org/10.1364/OL.35.002094


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Abstract

We demonstrate the feasibility of estimating hemoglobin oxygen saturation ( Sa O 2 ) from erythrocytes over a visible wavelength band using high-resolution spectroscopic optical coherence tomography (SOCT). We take SOCT spectra from individual cells on in vitro human blood phantoms and calculate Sa O 2 by fitting the spectra to an analytical model. We also use diffusive spectroscopy (DS) measurements, which is validated by direct measurement of oxygen partial pressure, as a comparison. The result shows a reliable linear association between the Sa O 2 derived from SOCT and the DS measurement, indicating this methodology has potential on in vivo applications to evaluate blood oxygenation.

© 2010 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 2, 2010
Revised Manuscript: May 21, 2010
Manuscript Accepted: May 26, 2010
Published: June 11, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Ji Yi and Xu Li, "Estimation of oxygen saturation from erythrocytes by high-resolution spectroscopic optical coherence tomography," Opt. Lett. 35, 2094-2096 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-12-2094

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