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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Time-resolved diffuse optical tomography with patterned-light illumination and detection

Jin Chen, Vivek Venugopal, Frederic Lesage, and Xavier Intes  »View Author Affiliations


Optics Letters, Vol. 35, Issue 13, pp. 2121-2123 (2010)
http://dx.doi.org/10.1364/OL.35.002121


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Abstract

This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.

© 2010 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 5, 2010
Revised Manuscript: May 6, 2010
Manuscript Accepted: May 9, 2010
Published: June 21, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Jin Chen, Vivek Venugopal, Frederic Lesage, and Xavier Intes, "Time-resolved diffuse optical tomography with patterned-light illumination and detection," Opt. Lett. 35, 2121-2123 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-13-2121

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