OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation

James R. McLaughlan, Ronald A. Roy, Hengyi Ju, and Todd W. Murray  »View Author Affiliations


Optics Letters, Vol. 35, Issue 13, pp. 2127-2129 (2010)
http://dx.doi.org/10.1364/OL.35.002127


View Full Text Article

Enhanced HTML    Acrobat PDF (445 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A technique to enhance the photoacoustic emissions from laser-heated nanoparticles is presented. Gold nano particle-doped phantoms are subjected to pulsed optical and ultrasound fields, resulting in bubble formation and collapse and producing strong acoustic emissions. The applied ultrasound field allows for cavitation at lower laser fluences than using light alone. The acoustic emission associated with bubble collapse well exceeds the direct photoacoustic response and is used to image a nanoparticle-doped region in a tissue phantom. The strong acoustic emission and low-threshold fluence associated with ultrasound-assisted cavitation make the technique well suited for nanoparticle-targeted biological imaging and tissue therapy.

© 2010 Optical Society of America

OCIS Codes
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7170) Medical optics and biotechnology : Ultrasound
(140.3945) Lasers and laser optics : Microcavities
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 5, 2010
Revised Manuscript: May 14, 2010
Manuscript Accepted: May 25, 2010
Published: June 16, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
James R. McLaughlan, Ronald A. Roy, Hengyi Ju, and Todd W. Murray, "Ultrasonic enhancement of photoacoustic emissions by nanoparticle-targeted cavitation," Opt. Lett. 35, 2127-2129 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-13-2127

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited