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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom

Anant Agrawal, T. Joshua Pfefer, Naureen Gilani, and Rebekah Drezek  »View Author Affiliations


Optics Letters, Vol. 35, Issue 13, pp. 2269-2271 (2010)
http://dx.doi.org/10.1364/OL.35.002269


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Abstract

We present a novel (to our knowledge) approach for measurement of the three-dimensional point spread function (PSF) of optical coherence tomography (OCT) systems using a nanoparticle-embedded phantom (NEP), toward development of standardized test methods for biophotonic imaging. The NEP comprises highly reflective plasmonic nanoparticles, homogeneously distributed in a transparent silicone matrix. OCT image volumes were analyzed to characterize PSFs in axial and lateral directions at a variety of locations in the NEP. Results indicate submicrometer agreement with conventional approaches to measure dimensions of the PSF. The NEP offers a robust approach for validating and comparing imaging performance of OCT devices.

© 2010 Optical Society of America

OCIS Codes
(110.3000) Imaging systems : Image quality assessment
(110.4850) Imaging systems : Optical transfer functions
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(350.4800) Other areas of optics : Optical standards and testing

ToC Category:
Imaging Systems

History
Original Manuscript: March 30, 2010
Manuscript Accepted: April 26, 2010
Published: June 29, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Anant Agrawal, T. Joshua Pfefer, Naureen Gilani, and Rebekah Drezek, "Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom," Opt. Lett. 35, 2269-2271 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-13-2269

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