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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 12 — Sep. 30, 2010

Self-referenced photonic molecule bio(chemical)sensor

Svetlana V. Boriskina and Luca Dal Negro  »View Author Affiliations


Optics Letters, Vol. 35, Issue 14, pp. 2496-2498 (2010)
http://dx.doi.org/10.1364/OL.35.002496


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Abstract

We report a new type of optical biosensor capable of differentiating between bulk and surface perturbations of the ambient refractive index as well as between specific and nonspecific binding of molecules on the sensor surface. The proposed detection scheme is based on tracking the shifts of hybridized bonding and antibonding optical modes in coupled optical microcavities (photonic molecules). We demonstrate that by using two measurements of spectral shifts it is possible to discriminate between surface and volume index perturbation, to detect specific target molecules in a complex environment and to estimate the thickness of thin layers of adsorbed molecules.

© 2010 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(230.5750) Optical devices : Resonators
(300.6490) Spectroscopy : Spectroscopy, surface
(230.4555) Optical devices : Coupled resonators
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(130.7408) Integrated optics : Wavelength filtering devices

ToC Category:
Remote Sensing and Sensors

History
Original Manuscript: April 23, 2010
Manuscript Accepted: June 4, 2010
Published: July 15, 2010

Virtual Issues
Vol. 5, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Svetlana V. Boriskina and Luca Dal Negro, "Self-referenced photonic molecule bio(chemical)sensor," Opt. Lett. 35, 2496-2498 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-14-2496


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References

  1. F. Vollmer and S. Arnold, Nature Meth. 5, 591 (2008). [CrossRef]
  2. A. M. Armani and K. J. Vahala, Opt. Lett. 31, 1896 (2006). [CrossRef] [PubMed]
  3. C. Y. Chao and L. J. Guo, Appl. Phys. Lett. 83, 1527 (2003). [CrossRef]
  4. M. Noto, F. Vollmer, D. Keng, I. Teraoka, and S. Arnold, Opt. Lett. 30, 510 (2005). [CrossRef] [PubMed]
  5. H. Beier, G. Coté, and K. Meissner, Ann. Biomed. Eng. 37, 1974 (2009). [CrossRef] [PubMed]
  6. A. Francois and M. Himmelhaus, Appl. Phys. Lett. 94, 031101 (2009). [CrossRef]
  7. F. Vollmer, S. Arnold, D. Braun, I. Teraoka, and A. Libchaber, Biophys. J. 85, 1974 (2003). [CrossRef] [PubMed]
  8. A. Yalcin, K. C. Popat, J. C. Aldridge, T. A. Desai, J. Hryniewicz, N. Chbouki, B. E. Little, O. King, V. Van, S. Chu, D. Gill, M. Anthes-Washburn, S. M. Ünlü, and B. Goldberg, IEEE J. Sel. Top. Quantum Electron. 12, 148 (2006). [CrossRef]
  9. S. V. Boriskina, in Photonic Microresonator Research and Applications, I.Chremmos, O.Schwelb, and N.Uzunoglu, eds. (Springer, Dordrecht, 2010).
  10. D. W. Mackowski, Proc. R. Soc. Edinb., A 433, 599 (1991).
  11. S. V. Boriskina, J. Opt. Soc. Am. B 23, 1565 (2006). [CrossRef]
  12. S. V. Boriskina, Opt. Lett. 32, 1557 (2007). [CrossRef] [PubMed]

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