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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 12 — Sep. 30, 2010

Prospects of molecular photoacoustic imaging at 1064 nm wavelength

Kimberly Homan, Seungsoo Kim, Yun-Sheng Chen, Bo Wang, Srivalleesha Mallidi, and Stanislav Emelianov  »View Author Affiliations


Optics Letters, Vol. 35, Issue 15, pp. 2663-2665 (2010)
http://dx.doi.org/10.1364/OL.35.002663


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Abstract

An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrast- enhanced PA imaging at a wavelength of 1064 nm . Of all the wavelengths tested in a range from 710 to 1064 nm , the background PA signal from tissue in vivo was lowest and more homogeneous at 1064 nm . For blood-laden tissue, the background PA signal was up to 70% less at 1064 nm . Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at 1064 nm increased 38% compared to 750 nm . Therefore, contrast-enhanced PA imaging at 1064 nm is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.

© 2010 Optical Society of America

OCIS Codes
(160.1050) Materials : Acousto-optical materials
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6930) Medical optics and biotechnology : Tissue
(160.4236) Materials : Nanomaterials
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Imaging Systems

History
Original Manuscript: March 2, 2010
Revised Manuscript: May 19, 2010
Manuscript Accepted: June 21, 2010
Published: July 30, 2010

Virtual Issues
Vol. 5, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Kimberly Homan, Seungsoo Kim, Yun-Sheng Chen, Bo Wang, Srivalleesha Mallidi, and Stanislav Emelianov, "Prospects of molecular photoacoustic imaging at 1064 nm wavelength," Opt. Lett. 35, 2663-2665 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-15-2663

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