OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 3 — Feb. 10, 2010

Two-photon microscopy by wavelength-swept pulses delivered through single-mode fiber

Jeon Woong Kang, Pilhan Kim, Carlo Amadeo Alonzo, Hyunsung Park, and Seok H. Yun  »View Author Affiliations


Optics Letters, Vol. 35, Issue 2, pp. 181-183 (2010)
http://dx.doi.org/10.1364/OL.35.000181


View Full Text Article

Enhanced HTML    Acrobat PDF (242 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Nonlinear microscopy through flexible fiber-optic catheters has potential in clinical diagnostic applications. Here, we demonstrate a new approach based on wavelength-swept narrowband pulses that permits simple fiber-optic delivery without need of the dispersion management and allows nonmechanical beam scanning. Using 0.86 ps pulses rapidly tuned from 789 nm to 822 nm at a sweep rate of 200 Hz , we demonstrate two-photon fluorescence and second-harmonic generation imaging through a 5 - m -long standard single-mode fiber.

© 2010 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(140.3600) Lasers and laser optics : Lasers, tunable
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: September 16, 2009
Revised Manuscript: November 30, 2009
Manuscript Accepted: December 3, 2009
Published: January 13, 2010

Virtual Issues
Vol. 5, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Jeon Woong Kang, Pilhan Kim, Carlo Amadeo Alonzo, Hyunsung Park, and Seok H. Yun, "Two-photon microscopy by wavelength-swept pulses delivered through single-mode fiber," Opt. Lett. 35, 181-183 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-2-181


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. W. Denk, J. H. Strickler, and W. W. Webb, Science 248, 73 (1990). [CrossRef] [PubMed]
  2. W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, Proc. Natl. Acad. Sci. U.S.A. 100, 7075 (2003). [CrossRef] [PubMed]
  3. D. Bird and M. Gu, Opt. Lett. 28, 1552 (2003). [CrossRef] [PubMed]
  4. G. P. Agrawal, Nonlinear Fiber Optics (Academic, 2001).
  5. W. Göbel, A. Nimmerjahn, and F. Helmchen, Opt. Lett. 29, 1285 (2004). [CrossRef] [PubMed]
  6. S. Ramachandran, M. F. Yan, J. Jasapara, P. Wisk, S. Ghalmi, E. Monberg, and F. V. Dimarcello, Opt. Lett. 30, 3225 (2005). [CrossRef] [PubMed]
  7. A. M. Larson and A. T. Yeh, Opt. Express 16, 14723 (2008). [CrossRef] [PubMed]
  8. M. T. Myaing, D. J. MacDonald, and X. Li, Opt. Lett. 31, 1076 (2006). [CrossRef] [PubMed]
  9. W. Piyawattanametha, E. D. Cocker, L. D. Burns, R. P. J. Barretto, J. C. Jung, H. Ra, O. Solgaard, and M. J. Schnitzer, Opt. Lett. 34, 2309 (2009). [CrossRef] [PubMed]
  10. G. J. Tearney, R. H. Webb, and B. E. Bouma, Opt. Lett. 23, 1152 (1998). [CrossRef]
  11. D. Yelin, C. Boudoux, B. E. Bouma, and G. J. Tearney, Opt. Lett. 32, 1102 (2007). [CrossRef] [PubMed]
  12. C. Boudoux, S. H. Yun, W. Y. Oh, W. M. White, N. V. Iftimia, M. Shishkov, B. E. Bouma, and G. J. Tearney, Opt. Express 13, 8214 (2005). [CrossRef] [PubMed]
  13. K. Shi, S. Yin, and Z. Liu, J. Microsc. 223, 83 (2006). [CrossRef] [PubMed]
  14. S. H. Yun, Opt. Lett. 30, 2660 (2005). [CrossRef] [PubMed]
  15. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, Nat. Med. 12, 1429 (2006). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited