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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor

V. Toccafondo, J. García-Rupérez, M. J. Bañuls, A. Griol, J. G. Castelló, S. Peransi-Llopis, and A. Maquieira  »View Author Affiliations


Optics Letters, Vol. 35, Issue 21, pp. 3673-3675 (2010)
http://dx.doi.org/10.1364/OL.35.003673


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Abstract

We report an experimental demonstration of single-strand DNA (ssDNA) detection at room temperature using a photonic-crystal-waveguide-based optical sensor. The sensor surface was previously biofunctionalized with ssDNA probes to be used as specific target receptors. Our experiments showed that it is possible to detect these hybridization events using planar photonic-crystal structures, reaching an estimated detection limit as low as 19.8 nM for the detection of the complementary DNA strand.

© 2010 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(130.5296) Integrated optics : Photonic crystal waveguides

ToC Category:
Integrated Optics

History
Original Manuscript: July 30, 2010
Revised Manuscript: September 14, 2010
Manuscript Accepted: September 29, 2010
Published: October 28, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Citation
V. Toccafondo, J. García-Rupérez, M. J. Bañuls, A. Griol, J. G. Castelló, S. Peransi-Llopis, and A. Maquieira, "Single-strand DNA detection using a planar photonic-crystal-waveguide-based sensor," Opt. Lett. 35, 3673-3675 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-21-3673


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