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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 6 — Apr. 8, 2010

Multibeam fluorescence diffuse optical tomography using upconverting nanoparticles

Haichun Liu, Can T. Xu, and Stefan Andersson-Engels  »View Author Affiliations

Optics Letters, Vol. 35, Issue 5, pp. 718-720 (2010)

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Fluorescence diffuse optical tomography (FDOT) is a biomedical imaging modality that can be used for localization and quantification of fluorescent molecules inside turbid media. In this ill-posed problem, the reconstruction quality is directly determined by the amount and quality of the information obtained from the boundary measurements. Regularly, more information can be obtained by increasing the number of excitation positions in an FDOT system. However, the maximum number of excitation positions is limited by the finite size of the excitation beam. In the present work, we demonstrate a method in FDOT to exploit the unique nonlinear power dependence of upconverting nanoparticles to further increase the amount of information in a raster-scanning setup by including excitation with two beams simultaneously. We show that the additional information can be used to obtain more accurate reconstructions.

© 2010 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 2, 2009
Revised Manuscript: December 18, 2009
Manuscript Accepted: January 11, 2010
Published: February 25, 2010

Virtual Issues
Vol. 5, Iss. 6 Virtual Journal for Biomedical Optics

Haichun Liu, Can T. Xu, and Stefan Andersson-Engels, "Multibeam fluorescence diffuse optical tomography using upconverting nanoparticles," Opt. Lett. 35, 718-720 (2010)

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