Nonlinear endomicroscopy using a double-clad fiber coupler
Optics Letters, Vol. 35, Issue 7, pp. 995-997 (2010)
http://dx.doi.org/10.1364/OL.35.000995
Enhanced HTML 
Acrobat PDF (333 KB)
Abstract
A double-clad fiber coupler is developed to be used in two-photon-excited fluorescence endomicroscopy to replace a dichroic mirror and separate the fluorescence signal from the excitation laser beam. With the double-clad fiber coupler, the endomicroscope becomes more compact, easier to be aligned, and more stable in alignment. The double-clad fiber coupler can transmit 62% of the excitation laser beam through the core. The fluorescence collection efficiency of the double-clad fiber coupler is 34%, which is, to the best of our knowledge, the highest fluorescence collection efficiency achieved by couplers used in two-photon-excited fluorescence endomicroscopes. As a result, the contrast of endomicroscopy imaging is enhanced.
© 2010 Optical Society of America
OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(180.2520) Microscopy : Fluorescence microscopy
ToC Category:
Microscopy
History
Original Manuscript: December 2, 2009
Revised Manuscript: February 8, 2010
Manuscript Accepted: February 19, 2010
Published: March 26, 2010
Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Hongchun Bao, Seon Young Ryu, Byeong Ha Lee, Wei Tao, and Min Gu, "Nonlinear endomicroscopy using a double-clad fiber coupler," Opt. Lett. 35, 995-997 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-7-995
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Related Journal Articles 
- Whole-field optically sectioned fluorescence lifetime imaging (OL)
- Multiple-objective microscopy with three-dimensional resolution near 100 nm and a long working distance (OL)
- Optical scanning holography as a technique for high-resolution three-dimensional biological microscopy (JOSAA)
- Multiple imaging axis microscopy improves resolution for thick-sample applications (OL)
- Scanning holographic microscopy with resolution exceeding the Rayleigh limit of the objective by superposition of off-axis holograms (AO)
Related Conference Papers
- Multidimensional tissue imaging by matrix assisted laser desorption/ionization-ion mobility-mass spectrometry: advantages, challenges, and prospects for proteomics
- Luminescence microscopy of UV written waveguides
- Security and Non Destructive Evaluation Application of High Speed Time Domain Terahertz Imaging
- Fast-Scanning Two-Photon Fluorescence Imaging Using a Microelectromechanical Systems (MEMS) Two-Dimensional Scanning Mirror
- 3-D Localization of Fluorescent Microparticles Using a Rotating Point Spread Function
« Previous Article | Next Article »
OSA is a member of 