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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 8 — Jun. 8, 2010

Nonlinear endomicroscopy using a double-clad fiber coupler

Hongchun Bao, Seon Young Ryu, Byeong Ha Lee, Wei Tao, and Min Gu  »View Author Affiliations


Optics Letters, Vol. 35, Issue 7, pp. 995-997 (2010)
http://dx.doi.org/10.1364/OL.35.000995


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Abstract

A double-clad fiber coupler is developed to be used in two-photon-excited fluorescence endomicroscopy to replace a dichroic mirror and separate the fluorescence signal from the excitation laser beam. With the double-clad fiber coupler, the endomicroscope becomes more compact, easier to be aligned, and more stable in alignment. The double-clad fiber coupler can transmit 62% of the excitation laser beam through the core. The fluorescence collection efficiency of the double-clad fiber coupler is 34%, which is, to the best of our knowledge, the highest fluorescence collection efficiency achieved by couplers used in two-photon-excited fluorescence endomicroscopes. As a result, the contrast of endomicroscopy imaging is enhanced.

© 2010 Optical Society of America

OCIS Codes
(110.6880) Imaging systems : Three-dimensional image acquisition
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Microscopy

History
Original Manuscript: December 2, 2009
Revised Manuscript: February 8, 2010
Manuscript Accepted: February 19, 2010
Published: March 26, 2010

Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Hongchun Bao, Seon Young Ryu, Byeong Ha Lee, Wei Tao, and Min Gu, "Nonlinear endomicroscopy using a double-clad fiber coupler," Opt. Lett. 35, 995-997 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-7-995


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