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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 9 — Jul. 6, 2010

Optimized speckle variance OCT imaging of microvasculature

Adrian Mariampillai, Michael K. K. Leung, Mark Jarvi, Beau A. Standish, Kenneth Lee, Brian C. Wilson, Alex Vitkin, and Victor X. D. Yang  »View Author Affiliations


Optics Letters, Vol. 35, Issue 8, pp. 1257-1259 (2010)
http://dx.doi.org/10.1364/OL.35.001257


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Abstract

We optimize speckle variance optical coherence tomography (svOCT) imaging of microvasculature in high and low bulk tissue motion scenarios. To achieve a significant level of image contrast, frame rates must be optimized such that tissue displacement between frames is less than the beam radius. We demonstrate that higher accuracy estimates of speckle variance can enhance the detection of capillaries. These findings are illustrated in vivo by imaging the dorsal window chamber model (low bulk motion). We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT.

© 2010 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 15, 2009
Revised Manuscript: February 5, 2010
Manuscript Accepted: February 8, 2010
Published: April 15, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Adrian Mariampillai, Michael K. K. Leung, Mark Jarvi, Beau A. Standish, Kenneth Lee, Brian C. Wilson, Alex Vitkin, and Victor X. D. Yang, "Optimized speckle variance OCT imaging of microvasculature," Opt. Lett. 35, 1257-1259 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-8-1257


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