Optimized speckle variance OCT imaging of microvasculature
Optics Letters, Vol. 35, Issue 8, pp. 1257-1259 (2010)
http://dx.doi.org/10.1364/OL.35.001257
Enhanced HTML 
Acrobat PDF (499 KB)
Abstract
We optimize speckle variance optical coherence tomography (svOCT) imaging of microvasculature in high and low bulk tissue motion scenarios. To achieve a significant level of image contrast, frame rates must be optimized such that tissue displacement between frames is less than the beam radius. We demonstrate that higher accuracy estimates of speckle variance can enhance the detection of capillaries. These findings are illustrated in vivo by imaging the dorsal window chamber model (low bulk motion). We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT.
© 2010 Optical Society of America
OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: December 15, 2009
Revised Manuscript: February 5, 2010
Manuscript Accepted: February 8, 2010
Published: April 15, 2010
Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics
Citation
Adrian Mariampillai, Michael K. K. Leung, Mark Jarvi, Beau A. Standish, Kenneth Lee, Brian C. Wilson, Alex Vitkin, and Victor X. D. Yang, "Optimized speckle variance OCT imaging of microvasculature," Opt. Lett. 35, 1257-1259 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-8-1257
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Multimedia
| Multimedia Files | Recommended Software |
| » Media 1: AVI (3693 KB) | QuickTime |
| » Media 2: AVI (1797 KB) | QuickTime |
You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Related Journal Articles 
- En face imaging of single cell layers by differential phase-contrast optical coherence microscopy (OL)
- High-speed optical frequency-domain imaging (OE)
- High-speed spectral-domain optical coherence tomography at 1.3 μm wavelength (OE)
- Speckle variance detection of microvasculature using swept-source optical coherence tomography (OL)
- Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography (BOE)
Related Conference Papers
- Quantitative Evaluation of Nanoshells as a Contrast Agent for Optical Coherence Tomography
- Bioconjugated Au/Ag Nanocages as a Novel Optical Imaging Contrast and Thermal Therapeutic Agent
- Pump-Probe Scheme for Optical Coherence Tomography Using Indocyanine Green Mixed with Albumin or Human Plasma
- Real-Time Ultrahigh-Resolution Lateral-Priority OCT Imaging with a Broad Spectrum Throughput Acousto-Optic Modulation
- An all-digital real-time optical coherence tomographic system
« Previous Article | Next Article »
OSA is a member of 