Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters
Optics Letters, Vol. 35, Issue 9, pp. 1314-1316 (2010)
http://dx.doi.org/10.1364/OL.35.001314
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Abstract
We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor–acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.
© 2010 Optical Society of America
OCIS Codes
(170.1420) Medical optics and biotechnology : Biology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(290.7050) Scattering : Turbid media
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: December 22, 2009
Revised Manuscript: February 18, 2010
Manuscript Accepted: February 25, 2010
Published: April 20, 2010
Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics
Citation
Vaibhav Gaind, Sumith Kularatne, Philip S. Low, and Kevin J. Webb, "Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters," Opt. Lett. 35, 1314-1316 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-9-1314
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