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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 9 — Jul. 6, 2010

Section-illumination photoacoustic microscopy for dynamic 3D imaging of microcirculation in vivo

Liang Song, Konstantin Maslov, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 35, Issue 9, pp. 1482-1484 (2010)
http://dx.doi.org/10.1364/OL.35.001482


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Abstract

We developed section-illumination photoacoustic microscopy capable of dynamic in vivo imaging of microvessels as small as 30 μm in diameter. The section illumination improved the elevational resolution while an ultrasound array provided the in-plane axial and lateral resolutions. Using the imaging system, we monitored the wash-in dynamics of Evans Blue in the microcirculation of mouse ears at 249 Hz 2D and 0.5 Hz 3D image acquisition rates. Such observation allowed us to differentiate the arterioles from the venules. In the future, the technology may be used to study angiogenesis, diabetes-induced vascular complications, and pharmacokinetics.

© 2010 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0180) Medical optics and biotechnology : Microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 17, 2010
Manuscript Accepted: March 18, 2010
Published: April 30, 2010

Virtual Issues
Vol. 5, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Liang Song, Konstantin Maslov, and Lihong V. Wang, "Section-illumination photoacoustic microscopy for dynamic 3D imaging of microcirculation in vivo," Opt. Lett. 35, 1482-1484 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-35-9-1482

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Supplementary Material


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