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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 7 — Jul. 27, 2011

Differential laser-induced perturbation spectroscopy using a deep-ultraviolet excimer laser

Sarah E. Smith, Leia M. Shanyfelt, Katherine D. Buchanan, and David W. Hahn  »View Author Affiliations


Optics Letters, Vol. 36, Issue 11, pp. 2116-2118 (2011)
http://dx.doi.org/10.1364/OL.36.002116


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Abstract

Here we demonstrate a unique optical sensing scheme based on deep-UV photochemical perturbation in combination with difference spectroscopy. Applying a sequence of optical probing, UV-laser-induced perturbation, and repeat optical probing coupled with difference spectroscopy provides a new spectral signature. We show a selective (sevenfold difference) optical response using a fluorescence probe for binary mixtures of organic dyes, and generate complementary spectral information derived from Raman scattering of the dipeptide glycine-glycine. We further extend the methodology to fluorescence-based imaging of an organic matrix.

© 2011 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.2530) Spectroscopy : Fluorescence, laser-induced
(300.6330) Spectroscopy : Spectroscopy, inelastic scattering including Raman
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 15, 2011
Revised Manuscript: April 5, 2011
Manuscript Accepted: May 9, 2011
Published: May 31, 2011

Virtual Issues
Vol. 6, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Sarah E. Smith, Leia M. Shanyfelt, Katherine D. Buchanan, and David W. Hahn, "Differential laser-induced perturbation spectroscopy using a deep-ultraviolet excimer laser," Opt. Lett. 36, 2116-2118 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-11-2116

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