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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 7 — Jul. 27, 2011

Cellular resolution optical coherence microscopy with high acquisition speed for in-vivo human skin volumetric imaging

Kye-Sung Lee, Kevin P. Thompson, Panomsak Meemon, and Jannick P. Rolland  »View Author Affiliations


Optics Letters, Vol. 36, Issue 12, pp. 2221-2223 (2011)
http://dx.doi.org/10.1364/OL.36.002221


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Abstract

In this Letter, we report for the first time (to our knowledge) in-vivo volumetric optical coherence microscopy images of skin epidermal cells. We achieved micrometer-class resolution, 2 μm laterally and axially, with an acquisition speed of 23 K A-scans/s and over 90 dB sensitivity to a depth of 1 mm by employing a custom, liquid-lens-based, dynamic-focusing objective, a broadband light source, and a custom, astigmatism-corrected Czerny–Turner spectrometer with a high-speed complementary metal-oxide-semiconductor camera.

© 2011 Optical Society of America

OCIS Codes
(170.1870) Medical optics and biotechnology : Dermatology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(220.4830) Optical design and fabrication : Systems design
(300.6190) Spectroscopy : Spectrometers
(180.1655) Microscopy : Coherence tomography

ToC Category:
Microscopy

History
Original Manuscript: March 14, 2011
Revised Manuscript: April 29, 2011
Manuscript Accepted: May 12, 2011
Published: June 7, 2011

Virtual Issues
Vol. 6, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Kye-Sung Lee, Kevin P. Thompson, Panomsak Meemon, and Jannick P. Rolland, "Cellular resolution optical coherence microscopy with high acquisition speed for in-vivo human skin volumetric imaging," Opt. Lett. 36, 2221-2223 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-12-2221

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