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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 8 — Aug. 26, 2011

Coherent Raman scanning fiber endoscopy

Brian G. Saar, Richard S. Johnston, Christian W. Freudiger, X. Sunney Xie, and Eric J. Seibel  »View Author Affiliations


Optics Letters, Vol. 36, Issue 13, pp. 2396-2398 (2011)
http://dx.doi.org/10.1364/OL.36.002396


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Abstract

Coherent Raman scattering methods allow for label-free imaging of tissue with chemical contrast and high spatial and temporal resolution. However, their imaging depth in scattering tissue is limited to less than 1 mm , requiring the development of endoscopes to obtain images deep inside the body. Here, we describe a coherent Raman endoscope that provides stimulated Raman scattering images at seven frames per second using a miniaturized fiber scanner, a custom-designed objective lens, and an optimized scheme for collection of scattered light from the tissue. We characterize the system and demonstrate chemical selectivity in mouse tissue images.

© 2011 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(190.4180) Nonlinear optics : Multiphoton processes
(290.5910) Scattering : Scattering, stimulated Raman

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 28, 2011
Revised Manuscript: May 7, 2011
Manuscript Accepted: May 13, 2011
Published: June 20, 2011

Virtual Issues
Vol. 6, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Brian G. Saar, Richard S. Johnston, Christian W. Freudiger, X. Sunney Xie, and Eric J. Seibel, "Coherent Raman scanning fiber endoscopy," Opt. Lett. 36, 2396-2398 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-13-2396


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