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Revisiting the normalized Born approximation: effects of scattering |
Optics Letters, Vol. 36, Issue 22, pp. 4329-4331 (2011)
http://dx.doi.org/10.1364/OL.36.004329
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Abstract
The normalized Born approximation has been suggested as a ratiometric method in fluorescence molecular tomography (FMT) applications, to account for heterogeneity variations. The method enabled practical inversions, as it offered fluorescence reconstruction accuracy over a wide range of absorption heterogeneity, while also accounting for unknown experimental factors, such as the various system gains and losses. Yet it was noted that scattering variations affect the robustness and accuracy. Herein we decompose the effects of absorption and scattering and capitalize on the recent development of hybrid FMT/x-ray computed tomography imaging methods to proposed amendments to the method, which improve the overall accuracy of the approach.
© 2011 Optical Society of America
OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: August 1, 2011
Revised Manuscript: September 23, 2011
Manuscript Accepted: October 7, 2011
Published: November 9, 2011
Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Thomas Pyka, Ralf Schulz, Angelique Ale, and Vasilis Ntziachristos, "Revisiting the normalized Born approximation: effects of scattering," Opt. Lett. 36, 4329-4331 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-22-4329
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