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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 2 — Feb. 1, 2012

Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography

Brian E. Applegate, Ryan L. Shelton, Simon S. Gao, and John S. Oghalai  »View Author Affiliations


Optics Letters, Vol. 36, Issue 23, pp. 4716-4718 (2011)
http://dx.doi.org/10.1364/OL.36.004716


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Abstract

Vibratory measurements of the structures of the ear are key to understanding much of the pathology in mouse models of hearing loss. Unfortunately the high-speed sampling required to interrogate the high end of the mouse hearing spectrum is beyond the reach of most optical coherence tomography (OCT) systems. To address this issue, we have developed an algorithm that enables phase-sensitive OCT measurements over the full range of the mouse hearing spectrum ( 4 90 kHz ). The algorithm phase-locks the line-trigger to the acoustic stimulation and then uses interleaved sampling to reconstruct the signal with higher temporal sampling. The algorithm was evaluated by measuring the vibratory response of mouse tympanic membrane to a pure tone stimulus.

© 2011 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.4940) Medical optics and biotechnology : Otolaryngology

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 31, 2011
Revised Manuscript: October 18, 2011
Manuscript Accepted: October 19, 2011
Published: December 1, 2011

Virtual Issues
Vol. 7, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Brian E. Applegate, Ryan L. Shelton, Simon S. Gao, and John S. Oghalai, "Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography," Opt. Lett. 36, 4716-4718 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-23-4716


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References

  1. S. S. Gao, A. Xia, T. Yuan, P. D. Raphael, R. L. Shelton, B. E. Applegate, and J. S. Oghalai, Opt. Express 19, 15415 (2011). [CrossRef] [PubMed]
  2. J. S. Oghalai, Curr. Opin. Otolaryngol Head Neck Surg. 12, 431 (2004). [CrossRef] [PubMed]
  3. M. A. Choma, A. K. Ellerbee, C. Yang, T. L. Creazzo, and J. A. Izatt, Opt. Lett. 30, 1162 (2005). [CrossRef] [PubMed]
  4. A. Xia, S. S. Gao, T. Yuan, A. Osborn, A. Bress, M. Pfister, S. M. Maricich, F. A. Pereira, and J. S. Oghalai, Dis. Models Mech. 3, 209 (2010). [CrossRef]
  5. M. Lauterbach and M. Schnecker, Evaluation Engineering 45, 14 (2006).
  6. L. Robles and M. A. Ruggero, Physiol Rev. 81, 1305 (2001). [PubMed]

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