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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 2 — Feb. 1, 2012

Subdiffraction scattered light imaging of gold nanoparticles using structured illumination

Bo-Jui Chang, Shiuan Huei Lin, Li-Jun Chou, and Su-Yu Chiang  »View Author Affiliations


Optics Letters, Vol. 36, Issue 24, pp. 4773-4775 (2011)
http://dx.doi.org/10.1364/OL.36.004773


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Abstract

A reflective light-scattering (RLS) microscope with structured illumination (SI) provides subdiffraction resolution and improves the image quality of gold nanoparticles in biological systems. The three-dimensional (3D)-structured pattern is rapidly and precisely controlled with a spatial light modulator and scrambled at the conjugate image plane to increase spatial incoherence. The reconstructed SI-RLS image of 100 nm gold nanoparticles reveals lateral and axial resolutions of approximately 117 and 428 nm. We present a high-resolution image of gold nanoparticles inside a HeLa cell, with improved contrast.

© 2011 Optical Society of America

OCIS Codes
(180.0180) Microscopy : Microscopy
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Microscopy

History
Original Manuscript: July 22, 2011
Revised Manuscript: September 28, 2011
Manuscript Accepted: October 20, 2011
Published: December 14, 2011

Virtual Issues
Vol. 7, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Bo-Jui Chang, Shiuan Huei Lin, Li-Jun Chou, and Su-Yu Chiang, "Subdiffraction scattered light imaging of gold nanoparticles using structured illumination," Opt. Lett. 36, 4773-4775 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-24-4773

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