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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 2 — Feb. 1, 2012

Multiscale multimodal imaging with multiphoton microscopy and optical coherence tomography

Shuo Tang, Yifeng Zhou, Kenny K. H. Chan, and Tom Lai  »View Author Affiliations


Optics Letters, Vol. 36, Issue 24, pp. 4800-4802 (2011)
http://dx.doi.org/10.1364/OL.36.004800


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Abstract

A multiscale multiphoton microscopy (MPM) and optical coherence tomography (OCT) system has been developed using a sub-10fs Ti:sapphire laser. The system performs cross-sectional OCT imaging over millimeter field-of-view and en-face high-resolution MPM imaging with submicrometer resolution from the same sample location. With fish cornea, we have demonstrated cross-sectional imaging of cornea tissue layers using OCT, and the zoom-in imaging of cells and collagen fibers in each layer using MPM. The multiscale MPM/OCT system shows the potential of a rapid coarse scan to search for abnormal regions and the subsequent fine zoom-in imaging for diagnosis.

© 2011 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: September 9, 2011
Revised Manuscript: November 4, 2011
Manuscript Accepted: November 8, 2011
Published: December 15, 2011

Virtual Issues
Vol. 7, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Shuo Tang, Yifeng Zhou, Kenny K. H. Chan, and Tom Lai, "Multiscale multimodal imaging with multiphoton microscopy and optical coherence tomography," Opt. Lett. 36, 4800-4802 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-24-4800


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