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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 4 — May. 4, 2011

Intravascular photoacoustic imaging of human coronary atherosclerosis

Krista Jansen, Antonius F. W. van der Steen, Heleen M. M. van Beusekom, J. Wolter Oosterhuis, and Gijs van Soest  »View Author Affiliations


Optics Letters, Vol. 36, Issue 5, pp. 597-599 (2011)
http://dx.doi.org/10.1364/OL.36.000597


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Abstract

We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1.25 mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230 nm . Simultaneous imaging with intravascular ultrasound was performed.

© 2011 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7170) Medical optics and biotechnology : Ultrasound

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 8, 2010
Revised Manuscript: January 13, 2011
Manuscript Accepted: January 26, 2011
Published: February 17, 2011

Virtual Issues
Vol. 6, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Krista Jansen, Antonius F. W. van der Steen, Heleen M. M. van Beusekom, J. Wolter Oosterhuis, and Gijs van Soest, "Intravascular photoacoustic imaging of human coronary atherosclerosis," Opt. Lett. 36, 597-599 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-36-5-597

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