OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 4 — May. 4, 2011

Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry

Rakesh Singh Moirangthem, Yia-Chung Chang, and Pei-Kuen Wei  »View Author Affiliations

Optics Letters, Vol. 36, Issue 5, pp. 775-777 (2011)

View Full Text Article

Enhanced HTML    Acrobat PDF (464 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6 × 10 6 RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to 18 pM concentration of the target biomolecules.

© 2011 Optical Society of America

OCIS Codes
(260.2130) Physical optics : Ellipsometry and polarimetry
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(250.5403) Optoelectronics : Plasmonics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 26, 2010
Revised Manuscript: January 19, 2011
Manuscript Accepted: February 2, 2011
Published: March 1, 2011

Virtual Issues
Vol. 6, Iss. 4 Virtual Journal for Biomedical Optics

Rakesh Singh Moirangthem, Yia-Chung Chang, and Pei-Kuen Wei, "Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry," Opt. Lett. 36, 775-777 (2011)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008). [CrossRef] [PubMed]
  2. P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007). [CrossRef] [PubMed]
  3. I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005). [CrossRef] [PubMed]
  4. N. Nath and A. Chilkoti, Anal. Chem. 76, 5370 (2004). [CrossRef] [PubMed]
  5. M. M. Miller and A. A. Lazarides, J. Phys. Chem. B 109, 21556 (2005). [CrossRef]
  6. T. Okamoto, I. Yamaguchi, and T. Kobayashi, Opt. Lett. 25, 372 (2000). [CrossRef]
  7. A. V. Kabashin, S. Patskovsky, and A. N. Grigorenko, Opt. Express 17, 21191 (2009). [CrossRef] [PubMed]
  8. W. K. Kuo and C. H. Chang, Opt. Express 18, 19656 (2010). [CrossRef] [PubMed]
  9. V. G. Karvets, F. Schedin, A. V. Kabashin, and A. N. Grigorenko, Opt. Lett. 35, 956 (2010). [CrossRef]
  10. H. Fujiwara, Spectroscopic Ellipsometry: Principles and Applications (Wiley, 2007).
  11. G. Frens, Nature 241, 20 (1973).
  12. N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003). [CrossRef]
  13. J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999). [CrossRef]
  14. J. Y. Lee, T. K. Chou, and H. C. Shih, Opt. Lett. 33, 434 (2008). [CrossRef] [PubMed]
  15. A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, Appl. Phys. Lett. 75, 3917 (1999). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited