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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 7 — Jun. 25, 2012

Pulse inversion ultrasound modulated optical tomography

Haowen Ruan, Melissa L. Mather, and Stephen P. Morgan  »View Author Affiliations


Optics Letters, Vol. 37, Issue 10, pp. 1658-1660 (2012)
http://dx.doi.org/10.1364/OL.37.001658


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Abstract

Pulse inversion acoustic imaging is useful as it allows second harmonic imaging to be obtained with short acoustic pulses. This allows high axial resolution, but removes any overlap in the frequency spectra of fundamental and harmonic. We demonstrate pulse inversion ultrasound modulated optical tomography using an optical speckle based detection method. Inverted and non-inverted acoustic pulses combined with synchronized strobed illumination are applied to an optically scattering medium. Over the acquisition time of a camera, multiple pulses are summed and at the next frame the phase of the ultrasound is shifted by π/2 and the process repeated. Combining the two frames allows a second harmonic signal to be obtained. A reduction in linewidth is observed (DC=9.26mm, fundamental=4.02mm, second harmonic=2.43mm) in line scans of optically absorbing objects embedded in a scattering medium (thickness=16mm, scattering coefficient=2.3mm1, anisotropy factor=0.938).

© 2012 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.1065) Medical optics and biotechnology : Acousto-optics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 4, 2011
Revised Manuscript: February 22, 2012
Manuscript Accepted: March 27, 2012
Published: May 9, 2012

Virtual Issues
Vol. 7, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Haowen Ruan, Melissa L. Mather, and Stephen P. Morgan, "Pulse inversion ultrasound modulated optical tomography," Opt. Lett. 37, 1658-1660 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-10-1658


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