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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 8 — Aug. 2, 2012

Focused cylindrical vector beam assisted microscopic pSPR biosensor with an ultra wide dynamic range

Rong Wang, Chonglei Zhang, Yong Yang, Siwei Zhu, and X.-C. Yuan  »View Author Affiliations


Optics Letters, Vol. 37, Issue 11, pp. 2091-2093 (2012)
http://dx.doi.org/10.1364/OL.37.002091


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Abstract

A novel phase-sensitive surface plasmon resonance (pSPR) biosensor based on differential phase measurement between two cylindrical vector beams, namely radially polarized and azmuthally polarized beams, is proposed and studied in an inverted microscope. Different from a fixed angle or a relatively small angular range for SPR excitation in the attenuated total reflection (ATR) configuration, the signal beam focused by a total internal reflection fluorescence microscopic objective contains the entire angular range from 0 to the maximum angle given by the numerical aperture, leading to a dynamic range of 0.41 RIU which is over seven times wider than the best result of the ATR pSPR sensor. Moreover, with the technique of differential phase measurement between radial and azimuthal polarizations employed in our configuration, high sensitivity of ±9.05×108 refractive index unit/1deg can simultaneously be achieved in principle. The proposed technique maintains the unique advantages in terms of securing high imaging resolution and sensitivity with an ultra-wide dynamic range simultaneously.

© 2012 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.5060) Instrumentation, measurement, and metrology : Phase modulation
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(240.6680) Optics at surfaces : Surface plasmons
(180.4243) Microscopy : Near-field microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 13, 2011
Revised Manuscript: February 21, 2012
Manuscript Accepted: April 11, 2012
Published: May 30, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Rong Wang, Chonglei Zhang, Yong Yang, Siwei Zhu, and X.-C. Yuan, "Focused cylindrical vector beam assisted microscopic pSPR biosensor with an ultra wide dynamic range," Opt. Lett. 37, 2091-2093 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-11-2091

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