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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 8 — Aug. 2, 2012

Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements

Mamadou Diop and Keith St. Lawrence  »View Author Affiliations


Optics Letters, Vol. 37, Issue 12, pp. 2358-2360 (2012)
http://dx.doi.org/10.1364/OL.37.002358


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Abstract

A nonparametric deconvolution algorithm for recovering the photon time-of-flight distribution (TOFD) from time-resolved (TR) measurements is described. The algorithm combines wavelet denoising and a two-stage deconvolution method based on generalized singular value decomposition and Tikhonov regularization. The efficacy of the algorithm was tested on simulated and experimental TR data and the results show that it can recover the photon TOFD with high fidelity. Combined with the microscopic Beer–Lambert law, the algorithm enables accurate quantification of absorption changes from arbitrary time-of-flight windows, thereby optimizing the depth sensitivity provided by TR measurements.

© 2012 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 16, 2012
Revised Manuscript: April 12, 2012
Manuscript Accepted: May 1, 2012
Published: June 12, 2012

Virtual Issues
Vol. 7, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Mamadou Diop and Keith St. Lawrence, "Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements," Opt. Lett. 37, 2358-2360 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-12-2358

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