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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 9 — Aug. 28, 2012

Line-scanning detection instrument for photonic crystal enhanced fluorescence

Vikram Chaudhery, Meng Lu, Cheng-Sheng Huang, James Polans, Ruimin Tan, Richard C. Zangar, and Brian T. Cunningham  »View Author Affiliations


Optics Letters, Vol. 37, Issue 13, pp. 2565-2567 (2012)
http://dx.doi.org/10.1364/OL.37.002565


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Abstract

A laser line-scanning instrument was developed to optimize the near-field enhancement capability of a one-dimensional photonic crystal (PC) for excitation of surface-bound fluorophores. The excitation laser beam is shaped into an 8μm×1mm line that is focused along the direction of the PC grating, while remaining collimated perpendicular to the grating. Such a beam configuration offers high excitation power density while simultaneously providing high resonant coupling efficiency from the laser to the PC surface. Using a panel of 21 immunofluorescence assays on the PC surface in a microarray format, the approach achieves an enhancement factor as high as 90-fold between on-resonance and off-resonance illumination. The instrument provides a capability for sensitive and inexpensive analysis of cancer biomarkers in clinical applications.

© 2012 Optical Society of America

OCIS Codes
(180.2520) Microscopy : Fluorescence microscopy
(130.5296) Integrated optics : Photonic crystal waveguides
(050.5298) Diffraction and gratings : Photonic crystals

ToC Category:
Diffraction and Gratings

History
Original Manuscript: February 16, 2012
Revised Manuscript: May 4, 2012
Manuscript Accepted: May 6, 2012
Published: June 21, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Vikram Chaudhery, Meng Lu, Cheng-Sheng Huang, James Polans, Ruimin Tan, Richard C. Zangar, and Brian T. Cunningham, "Line-scanning detection instrument for photonic crystal enhanced fluorescence," Opt. Lett. 37, 2565-2567 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-13-2565


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References

  1. N. Ganesh, W. Zhang, P. C. Mathias, E. Chow, J. Soares, V. Malyarchuk, A. D. Smith, and B. T. Cunningham, Nat. Nanotechnol. 2, 515 (2007). [CrossRef]
  2. T. Kaji, T. Yamada, R. Ueda, and A. Otomo, J. Phys. Chem. Lett. 2, 1651 (2011). [CrossRef]
  3. M. Li, P. Zhang, J. Li, J. Zhou, A. Sinitskii, V. Abramova, S. O. Klimonsky, and Y. D. Tretyakov, Appl. Phys. B 89, 251 (2007). [CrossRef]
  4. A. Pokhriyal, M. Lu, V. Chaudhery, C.-S. Huang, S. Schulz, and B. T. Cunningham, Opt. Express 18, 24793 (2010). [CrossRef]
  5. I. V. Soboleva, E. Descrovi, C. Summonte, A. A. Fedyanin, and F. Giorgis, Appl. Phys. Lett. 94, 231122 (2009). [CrossRef]
  6. N. Ganesh, P. C. Mathias, W. Zhang, and B. T. Cunningham, J. Appl. Phys. 103, 083104 (2008). [CrossRef]
  7. A. Brzezinski, J.-T. Lee, J. D. Slinker, G. G. Malliaras, P. V. Braun, and P. Wiltzius, Phys. Rev. B 77, 233106 (2008). [CrossRef]
  8. C.-S. Huang, S. George, M. Lu, V. Chaudhery, R. Tan, R. C. Zangar, B. T. Cunningham, Anal. Chem. 83, 1425 (2011). [CrossRef]
  9. P. C. Mathias, S. I. Jones, H. Y. Wu, F. Yang, N. Ganesh, D. O. Gonzalez, G. Bollero, L. O. Vodkin, and B. T. Cunningham, Anal. Chem. 82, 6854 (2010). [CrossRef]
  10. V. Chaudhery, C.-S. Huang, A. Pokhriyal, J. Polans, and B. T. Cunningham, Opt. Express 19, 23327 (2011). [CrossRef]
  11. I. D. Block, P. C. Mathias, N. Ganesh, S. I. Jones, B. R. Dorvel, V. Chaudhery, L. O. Vodkin, R. Bashir, and B. T. Cunningham, Opt. Express 17, 13222 (2009). [CrossRef]
  12. V. Chaudhery, M. Lu, A. Pokhriyal, S. Schulz, and B. Cunningham, IEEE Sens. J. 12, 1272 (2011).
  13. P. C. Mathias, H.-Y. Wu, and B. T. Cunningham, Appl. Phys. Lett. 95, 021111 (2009). [CrossRef]

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