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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 9 — Aug. 28, 2012

Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence  »View Author Affiliations

Optics Letters, Vol. 37, Issue 13, pp. 2571-2573 (2012)

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Optical dye-dilution techniques can quantify kinetic parameters in a region of tissue, but currently rely on a two-step process—spatial reconstruction of the dye concentration, repeated at every time-point, and subsequent kinetic analysis of the time-dependent change in dye concentration. Inaccuracies, in this approach, are due mainly to the ill-posed nature of the spatial reconstruction problem, which propagates into kinetic analysis and result in errors in extracted dynamic parameters. We present a hybrid kinetic deconvolution optical reconstruction algorithm, effectively combining optical reconstruction and model-independent kinetic analysis into a single inverse problem that is better posed. Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios.

© 2012 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 7, 2012
Revised Manuscript: April 16, 2012
Manuscript Accepted: May 15, 2012
Published: June 22, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence, "Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters," Opt. Lett. 37, 2571-2573 (2012)

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