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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 9 — Aug. 28, 2012

Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper

Baolei Li, Kevin E. Claytor, Hsiangkuo Yuan, Tuan Vo-Dinh, Warren S. Warren, and Martin C. Fischer  »View Author Affiliations

Optics Letters, Vol. 37, Issue 13, pp. 2763-2765 (2012)

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Homodyne detection can dramatically enhance measurement sensitivity for weak signals. In nonlinear optical microscopy it can make accessible a range of novel, intrinsic, contrast like nonlinear absorption and nonlinear phase contrast. Here a compact and rapid pulse shaper is developed, implemented, and demonstrated for homodyne detection in nonlinear microscopy with high-repetition rate mode-locked femtosecond lasers. With this method we generate two-photon absorption (TPA) and self-phase modulation images of gold nanostars in biological samples. Simultaneous imaging of two-photon luminescence and TPA also enables us to produce two-photon quantum yield images.

© 2012 Optical Society of America

OCIS Codes
(190.7110) Nonlinear optics : Ultrafast nonlinear optics
(320.5540) Ultrafast optics : Pulse shaping
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:

Original Manuscript: February 28, 2012
Manuscript Accepted: April 25, 2012
Published: June 29, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Baolei Li, Kevin E. Claytor, Hsiangkuo Yuan, Tuan Vo-Dinh, Warren S. Warren, and Martin C. Fischer, "Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper," Opt. Lett. 37, 2763-2765 (2012)

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