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Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 9 — Aug. 28, 2012

Coherence-multiplexed, label-free biomolecular interaction analysis

Sajal Chirvi, Zexuan Qiang, and Digant P. Davé  »View Author Affiliations


Optics Letters, Vol. 37, Issue 14, pp. 2952-2954 (2012)
http://dx.doi.org/10.1364/OL.37.002952


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Abstract

This Letter describes an interferometric technique based on the principle of coherence multiplexing for multichannel, label-free biosensing applications. Multiple biosensors can be interrogated simultaneously with a single spectral-domain, phase-sensitive interferometer by coding the individual sensograms in coherence-multiplexed channels. The experimental results demonstrate the multiplexed quantitative biomolecular interaction of antibodies binding to antigen-coated functionalized biosensor chip surfaces. The described technique also applies to a variety of other distributed and multiplexed sensing applications besides biosensing.

© 2012 Optical Society of America

OCIS Codes
(030.1640) Coherence and statistical optics : Coherence
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(120.0280) Instrumentation, measurement, and metrology : Remote sensing and sensors
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Coherence and Statistical Optics

History
Original Manuscript: January 9, 2012
Revised Manuscript: May 8, 2012
Manuscript Accepted: May 22, 2012
Published: July 13, 2012

Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Sajal Chirvi, Zexuan Qiang, and Digant P. Davé, "Coherence-multiplexed, label-free biomolecular interaction analysis," Opt. Lett. 37, 2952-2954 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-14-2952


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