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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 10 — Oct. 5, 2012

Optical time-stretch confocal microscopy at 1  μm

Terence T. W. Wong, Andy K. S. Lau, Kenneth K. Y. Wong, and Kevin K. Tsia  »View Author Affiliations

Optics Letters, Vol. 37, Issue 16, pp. 3330-3332 (2012)

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We demonstrate optical time-stretch confocal microscopy in the 1  μm spectral window for high-speed and high-resolution cellular imaging. In contrast to the prior demonstrations of time-stretch imaging, which all operated in the telecommunication band, the present work extends the utility of this imaging modality to a wavelength regime (1μm), which is well known to be the optimal diagnostic window in biophotonics. This imaging technique enables us to image the nasopharyngeal epithelial cells with cellular resolution (<2μm), at a line scan rate of 10 MHz, and with a field of view as wide as 0.44mm×0.1mm. We also theoretically and experimentally characterized the system performance. As the low-loss dispersive fibers for the time-stretch process as well as other essential optical components for enhancing the imaging sensitivity are commonly available at 1  μm, time-stretch confocal microscopy in this wavelength range could usher in realizing high-speed cell imaging with an unprecedented throughput.

© 2012 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.7160) Medical optics and biotechnology : Ultrafast technology
(180.1790) Microscopy : Confocal microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 7, 2012
Manuscript Accepted: June 10, 2012
Published: August 6, 2012

Virtual Issues
Vol. 7, Iss. 10 Virtual Journal for Biomedical Optics

Terence T. W. Wong, Andy K. S. Lau, Kenneth K. Y. Wong, and Kevin K. Tsia, "Optical time-stretch confocal microscopy at 1  μm," Opt. Lett. 37, 3330-3332 (2012)

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